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LABORATORIO DE QUÍMICA ORGÁNICA Y BIOMOLECULAR (LQOBio)

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PUBLICACIONES
2017

Robles Marin, E.; Sánchez, C.A. & Urbina Gonzalez, J.M. "A mild procedure for the synthesis of allyl and benzyl α-hydroxyesters using O-allyl(benzyl)-N,N'-dicyclohexylisourea". Rev. Soc. Quím. Perú, 2017, 83(2), 143-159.
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2016

Quintana Mendoza, J.H.; Henao, J.A.; Robles Marin, E. & Urbina Gonzalez, J.M. "4-Benzyloxy-1-oxaspiro[4.6]undec-3-en-2-one". IUCrData, 2016, 1, x161538. (DOI: 10.1107/S2414314616015388)
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2015

Kouznetsov, V.V.; Puerto Galvis, C.E.; García Santos, W.H. “Gd(OTf)3-catalyzed synthesis of geranyl esters for the intramolecular radical cyclization of their epoxides mediated by titanocene(III)”. Org. Biol. Chem., 2015, 13, p. 1358-1366.
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León-Rojas, A.F.; Urbina-González, J.M. "Las furan-2[5H]-onas (Δα,β-butenolidas), su preparación e importancia biológica". Avances en Química, 2015, 10(1), p. 67-78.
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2014

Puerto Galvis, C.E.; Muñoz Acevedo, A.; Aristizabal Córdoba, S.; Kouznetsov, V.V. “Estudio químico-biológico de los aceites esenciales de Croton malambo H. Karst y su componente mayoritario, metileugenol”. Bol. Latinoam. Caribe Plant. Med. Aromat., 2014, 13 (4), p. 336-343.
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Merchán Arenas, D.R.; Kouznetsov, V.V. “Diastereoselective Synthesis of Dihydroisoindolo[2,1-a]quinolin-11-ones by Solvent-Free AMCell-SO3H-Catalyzed Imino Diels-Alder/Intramolecular Amide Cyclization Cascade Reactions”. J. Org. Chem., 2014, 79 (11), p. 5327-5333.
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Romero Bohorquez, A.R.; Kouznetsov, V.V.; Sanchez, A.; Camargo, H.A.; Henao, J.A. “Synthesis and X-ray diffraction data of 2-ethyl-6-(pyridin-4-yl)-7H-indeno[2,1-c]quinoline”. Powder Diffr., 2014, 29 (1), p. 53-57.
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Kouznetsov, V.V.; Carreño Otero, A.L.; Duque Luna, J.E.; Vargas Mendez, L.Y. “Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever”. Eur. J. Med. Chem., 2014, 78, p. 392-400.
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2013

Puerto Galvis, C.E.; Kouznetsov, V.V. “An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using zebrafish embryo model”. Org. Biol. Chem., 2013, 11 (3), p. 407-411.

Romero Bohórquez, A.R.; González, T.; Kouznetsov, V.V. “Synthesis and Crystal Structure of Two Nitro-Regioisomers of cis-4-(4-Methoxyphenyl)-3-Methyl-2-Phenyl-1,2,3,4-Tetrahydroquinoline”. Universitas Scientiarum, 2013, 18 (1), p. 65-72.

Leal P., S.M.; Amado T., D.F.; Kouznetsov, V.V.; Escobar, P. “In vitro antileishmanial, trypanocidal and mammalian cell activities of diverse N,N´-dihetaryl substituted diamines and related compounds“. Sci. Pharm., 2013, 81(1), p. 43-55.

Merchan Arenas, D.R.; Martínez Bonilla, C.A.; Kouznetsov, V.V. “Aqueous SDS micelle-promoted acid-catalyzed domino ABB’ imino Diels-Alder reaction: a mild and efficient synthesis of privileged 2-methyl-tetrahydroquinoline scaffolds”. Org. Biol. Chem., 2013, 11 (22), 3655–3663.

Puerto Galvis, C.E.; Hernández Barajas, J.G.; Kouznetsov, V.V. “Yb(OTf)3-Catalyzed Bromination Reactions of Natural Product-like N-Benzyl Cinnamamides: a Facile Route to Diverse N-Substituted Amides of Pharmacological Interest”. Curr. Org. Chem., 2013, 17 (14), 1545-1554.

Vargas Méndez, L.Y.; Kouznetsov, V.V. “First Girgensohnine Analogs prepared through InCl3-catalyzed Strecker Reaction and their Bioprospection”. Curr. Org. Synth., 2013, 10 969-973.

Bomparta, D.; Núñez-Durán, J.; Rodríguez, D.; Kouznetsov, V.V.; Meléndez Gómez, C.M.; Sojo, F.; Arvelo, F.; Visbal, G.; Alvarez, A.; Serrano-Martína, X.; García-Marchán, Y. "Anti-leishmanial evaluation of C2-aryl quinolines. Mechanistic insight on bioenergetics and sterol biosynthetic pathway of Leishmania braziliensis parasite". Bioorg. Med. Chem., 2013, 21 (14), 4426-4431.

Fonseca-Berzal, C.; Merchán Arenas, D.R.; Romero Bohórquez, A.R.; Escario, J.A.; Kouznetsov, V.V.; Gómez-Barrio, A. "Selective activity of 2,4-diaryl-1,2,3,4-tetrahydroquinolines on Trypanosoma cruzi epimastigotes and amastigotes expressing β-galactosidase". Bioorg. Med. Chem. Lett., 2013, 23 (17), 4851-4856.

Puerto Galvis, C.E.; Vargas Méndez, L.Y.; Kouznetsov, V.V. "Cantharidin-Based Small Molecules as Potential Therapeutic Agents". Chem. Biol. Drug Des., 2013, 82, 477-499.

Puerto Galvis, C.E.; Kouznetsov, V.V. "Regio- and stereoselective synthesis of spirooxindole 1’-nitro pyrrolizidines with five concurrent stereocenters under aqueous media and their bioprospection using the zebrafish (Danio rerio) embryo model". Org. Biol. Chem., 2013, 11(42), 7372-7386.

Díaz-Duran, L.D.; Olivar-Rincón, N.; Puerto Galvis, C.E.; Kouznetsov, V.V.; Fuentes, J.L. "Genotoxicity risk assessment of diversely substituted quinolines using the SOS chromotest". Environmental Toxicology, 2013, DOI: 10.1002/tox.21905

Acelas, M.; Gil, E.; Doerr, M.; Daza, M.C.; Urbina, J.M. "Synthesis of new N-phenyl-N-(1-phenylhex-5-en-1-yl)acetamides and their 1H-NMR conformational study". Rev. Colomb. Quím., 2013, 42(1), 5-12.

Quintana, J.H.; Henao, J.A.; Robles, E.; Urbina, J.M. "Synthesis and X-ray diffraction data of 4-benzyloxy-1-oxaspiro-[4.6]-undec-3-en-2-one". Powder Diffraction, 2013, 28(4), 315-320.

Roa, D.; Urbina, J.M. "Obtención de 2-fenil lepidinas durante la alquilación de Friedel-Crafts asistida por microondas de N-(α-alilbencil)anilinas soportadas en sílica-ácido sulfúrico". Ingeniería y Competitividad, 2013, 15(1), 71-77.


2012

Bueno, J.; Rojas Ruiz, F.A.; Villabona Estupiñan, S.; Kouznetsov, V.V. “In vitro antimycobacterial activity of new 7-chloroquinoline derivatives”. Letters in Drug Design & Discovery, 2012, 9 (2), p. 126-134.

Vizcaya, L.A.; Mora, A.J.; Delgado, G.E.; Bahsas, A.; Mora, U.; Kouznetsov, V.V. “The Crystal Structure of 1-[2-(furan-2-yl)-6-methyl-1,2,3,4-tetrahydroquinolin-4-yl]Pyrrolidin-2-one”. J. Chem. Crystallogr., 2012, 42 (3), p. 267-270.

Kouznetsov, V.V.; Meléndez Gómez, C.M.; Rojas Ruíz, F.A.; del Olmo, E. “Simple entry to new 2-alkyl-1,2,3,4-tetrahydroquinoline and 2,3-dialkylquinoline derivatives using BiCl3-catalyzed three component reactions of anilines and aliphatic aldehydes in the presence (or lack) of N-vinyl amides”. Tetrahedron Lett., 2012, 53 (20), p. 3115-3118.

Castillo-Garit, J.A.; del Toro-Cortés, O.; Kouznetsov, V.V.; Ochoa Puentes, C.; Romero Bohórquez, A.R.; Vega, M.C.; Rolón, M.; Escario, J.A.; Gómez-Barrio, A.; Marrero-Ponce, Y.; Torrens, F.; Abad, C. “Identification in silico and in vitro of novel trypanosomicidal drug-like compounds”. Chem. Biology & Drug Design, 2012, 80 (1), p. 38-45.

Kouznetsov, V.V.; Rojas Ruíz, F.A.; Vargas Méndez, L.Y.; Gupta, M.P. “Simple C-2-substituted quinolines and their anticancer activity”. Letters in Drug Design & Discovery, 2012, 9 (7), p. 680-686.

Muñoz, A.; Perticara, M.; Sojo, F.; Merchan Arenas, D.R.; Bello Forero, J.S.; Suarez, A.; Benaim, G.; Galindo-Castro, I.; Compagnone, R.; Kouznetsov, V.; Arvelo, F. “Tetrahidroquinolinas: Compuestos de origen sintéticos con propiedades antitumorales sobre líneas de cáncer humano”. Memorias del Instituto de Biología Experimental (ISSN 1316-7510), 2012, 6, p. 77-80.

Romero Bohórquez, A.R.; Escobar Rivero, P.; Leal, S.M.; Kouznetsov, V.V. “In vitro Activity against Trypanosoma cruzi and Leishmania chagasi Parasites of 2,4-Diaryl 1,2,3,4-Tetrahydroquinoline Derivatives”. Letters in Drug Design & Discovery, 2012, 9 (8), p. 802-808.

Sandoval, M.V.; Henao, J.A.; Romero Bohórquez, A.R.; Kouznetsov, V.V. “Synthesis and X-ray diffraction data of 5-Acryloyloxy-trans-2-(4-methoxyphenyl)-3-methyl-2,3-dihydrobenzo[b]furan”. Powder Diffraction, 2012, 27 (3), p. 211-214.

Kouznetsov, V.V.; Meléndez Gómez, C.M.; Derita, M.G.; Svetaz, L.; del Olmo, E.; Zacchino, S.A. “Synthesis and antifungal activity of diverse C-2 pyridinyl and pyridinylvinyl substituted quinolines”. Bioorg. Med. Chem., 2012, 20 (12), p. 6506-6512.

Kouznetsov, V.V.; Zacchino, S.A.; Sortino, M.; Vargas Méndez, L.Y.; Gupta, M.P. “Cytotoxic and antifungal activities of new α-naphtylamine derivatives”. Sci. Pharm., 2012, 80 (4), p. 867-877.

Restrepo, R.; Reyes, D.; Ortiz, M.C.; Rojas Ruiz, F.A.; Kouznetsov, V.V. “Aberraciones cromosomales en bulbos de cebolla Allium cepa inducidas por moléculas híbridas 4-aminoquinolínicas”. Universitas Scientiarum, 2012, 17 (3), p. 253-261.

Pinilla, J.A.; Henao, J.A.; Macías, M.A.; Romero Bohórquez, A.R.; Kouznetsov, V.V. “Synthesis and X-ray powder diffraction data of N-benzyl-6-chloro-4-(4-methoxyphenyl)-3-methyl-1,2,3,4-tetrahydroquinoline”. Powder Diffraction, 2012, 27 (4), p. 269-272.

Puerto-Galvis, C.E.; Kouznetsov, V.V. “Modelo de pez cebra y pequeñas moléculas heterocíclicas: actualidades y futuro”. Actual. Biol., 2012, 34 (96), 126-127.

Correa-Royero, J.; Puerto, C.; Kouznetsov, V.; Rojas-López, M.; Betancur-Galvis, L. “Actividad citóxica de híbridos de la combrestatina A4”. Actual. Biol., 2012, 34 (96), 129.

Merchán-Arenas, D.; Kouznetsov, V.V. “Nuevas librerías de tetrahidroquinolinas funcionalizadas como agentes antivirales y antitumorales”. Actual. Biol., 2012, 34 (96), 127-128.

Kouznetsov, V.V. “Retos y perspectivas de la biología química, una exitosa área multidisciplinaria de ciencias exactas y naturales”. Actual. Biol., 2012, 34 (96), 123.


2011

Rojas Ruiz, F.A.; Kouznetsov, V.V. “Property-based Design and Synthesis of New Chloroquine Hybrids via Simple Incorporation of 2-Imino-thiazolidin-4-one or 1H-Pyrrol-2,5-dione Fragments on the 4-Amino-7-chloroquinolines Side Chain”. J. Braz. Chem. Soc., 2011, 22 (9), p. 1774-1781.

Muñoz-Acevedo, A.; Stashenko, E.E.; Kouznetsov, V.V.; Martínez, J.R. “Differentiation of leaf and flower extracts of basil (Ocimum sp.) varieties grown in Colombia”. Journal of Essential Oil Bearing Plants, 2011, 15 (1), p. 1-9.

Bermúdez, J.H.; Pinto, J.L.; Meléndez, C.M.; Henao, J.A.; Kouznetsov, V.V. "Simple preparation of new N-(6-methyl-2-nitrophenyl-1,2,3,4-tetrahydroquinolin-4-yl) pyrrolidin-2-ones and their spectroscopic analysis". Universitas Scientiarum, 2011, 16(2), p. 161-168.

Kouznetsov, V.V.; Meléndez Gómez, C.M.; Luna Parada, L.K.; Bermudez, J.H.; Vargas Méndez, L.Y.; Muñoz Acevedo, A. "Efficient synthesis and free-radical scavenging capacity of new 2,4-substituted tetrahydroquinolines prepared via BiCl3-catalyzed three-component Povarov reaction, using N-vinylamides". Mol. Diversity, 2011, 15(4), p. 1007-1016.

Merchán Arenas, D.R.; Muñoz Acevedo, A.; Vargas Méndez, L.Y.; Kouznetsov, V.V. "Scavenger activity evaluation of the clove bud essential oil (Eugenia caryophyllus) and eugenol derivatives employing ABTS+• decolorization". Sci. Pharm., 2011, 79(4), p. 779-791.

Kouznetsov, V.V.; Merchan Arenas, D.R.; Ortiz Areniz, C.J.; Meléndez Gómez, C.M. "Inexpensive Phthalic Acid promoted Domino Povarov Reaction between Anilines and N-Vinyl Amides: An Efficient Preparation of Privileged 4-Substituted 2-Methyl-1,2,3,4-tetrahydroquinoline Scaffolds". Synthesis, 2011, 24, p. 4011-4016.

Mora, J.; Gélvez, O.; Castro, J.; Roa, D.; Flórez, S.; Urbina, J.M. "Diodos orgánicos emisores de luz (OLEDs) y sus bases tecnológicas". Sci. Tech., 2011, 49, p. 199-206.

Garibotto, F.M.; Sortino, M.A.; Kouznetsov, V.V; Enriz, R.D.; Zacchino, S.A. ”Synthesis and antifungal activity of N-aryl-N-benzylamines and of their homoallyl- analogues”. Arkivoc, 2011, vii, p. 149-161.

Merchan Arenas, D.R.; Rojas Ruiz, F.A.; Kouznetsov, V.V. “Highly diastereoselective synthesis of new heterolignan-like 6,7-methylendioxy-tetrahydroquinolines using the clove bud essential oil as raw material”. Tetrahedron Lett., 2011, 52, p. 1388-1391.

Camargo, H.A.; Habran, N.M.; Henao, J.J.; Amado, D.F.; Kouznetsov, V.V. “Synthesis and X-ray diffraction data of 1-[N-(methyl)-(3,5-dimethylphenylamino)]methylnaphthalene”. Powder Diffraction, 2011, 26 (1), p. 74-77.

Rojas Ruiz, F.A.; Vargas Méndez, L.Y.; Kouznetsov, V.V. “Challenges and Perspectives of Chemical Biology, a Successful Multidisciplinary Field of Natural Sciences”. Molecules, 2011, 16 (3), p. 2672-2687.

Muñoz-Acevedo, A.; Vargas Méndez, L.Y.; Stashenko, E.E.; Kouznetsov, V.V. “Improved Trolox® equivalent antioxidant capacity assay for efficient and fast search of new antioxidant agents”. Analytical Chemistry Letters, 2011, 1 (1), p. 86-102.

Rojas Ruiz, F.A.; García-Sánchez, R.N.; Villabona Estupiñan, S.; Gómez-Barrio, A.; Amado Torres, D.F.; Pérez-Solórzano, B.M.; Nogal-Ruiz, J.J.; Martínez-Fernández, A.R.; Kouznetsov, V.V. “Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds”. Bioorg. Med. Chem., 2011, 19 (15), p. 4562-4573.

Vargas Méndez, L.Y.; Kouznetsov, V.V. ”Intramolecular N to N Acyl Migration in Conformationally Mobile 1´-Acyl-1-benzyl-3´,4´-dihydro-1´H-spiro[piperidine-4,2´-quinoline] Systems Promoted by Debenzylation Conditions (HCOONH4/Pd/C)”. Cent. Eur. J. Chem., 2011, 9 (5), p. 877-885.

Kouznetsov, V.V. “The chemistry-biology interface: why and how do educate future chemical biologists”. Journal of Science Education, 2011, 12 (1), p. 17-21.

Romero Bohórquez, A.R.; Kouznetsov, V.V.; Doyle M.P. “Cu(OTf)2-Catalyzed Three-Component Imino Diels-Alder Reaction Using Propenylbenzenes: Synthesis of 2,4-Diaryl Tetrahydroquinoline Derivatives”. Lett. Org. Chem., 2011, 8 (1), p. 5-11.

Muñoz, A.; Sojo, F.; Merchan Arenas, D.; Kouznetsov, V.V.; Arvelo, F. “Cytotoxic effects of new trans 2,4-diaryl-r-3-methyl-1,2,3,4-tetrahydroquinolines and their interaction with antitumoral drugs gemcitabine and paclitaxel on cellular lines of human breast cancer”. Chemico-Biological Interactions, 2011, 189 (3), p. 215-221.


2010

Bello, J.S.; Amado, F.; Henao, A.; Atencio, R.; Kouznetsov, V.V. "Simple preparation of new N-aryl-N-(3-indolmethyl) acetamides and their spectroscopic analysis". Universitas Scientiarum, 2010, 14 (2-3), p. 216-224.

Romero Bohórquez, A.R.; Kouznetsov, V.V.; González, T.; Briceño, A. "2-Ethyl-6-(2-pyridyl)-5,6,6a,11b-tetrahydro-7H-indeno[2,1-c]quinoline". Acta Cryst., 2010, E66, o680-o681.

Nikitina, E.V.; Khrustalev, V.N.; Grudinin, D.G.; Toze Flavien, A.A.; Kouznetsov, V.V.; Zubkov, F.I. "First example of Diels-Alder reaction in the 2,3,4,4a-tetrahydroquinoline series. Synthesis of hydrogenated 5,8-ethanoquinolines". Tetrahedron, 2010, 66(15), p. 2889-2894.

Vargas, L.Y.; Zacchino, S.; Kouznetsov, V.V. "Synthesis of new 4-methyl-2-(4-pyridyl)-1,2,3,4-tetrahydroquinolines as potent antifungal compounds". J. Braz. Chem. Soc., 2010, 21(1), p. 105-111.

Castillo-Garit, J.A.; Vega, M.C.; Rolon, M.; Marrero-Ponce, Y.; Kouznetsov, V.V.; Torres D., F.A.; Gómez-Barrio, A.; Bello, A.A.; Montero, A.; Torrens, F.; Pérez-Giménez, F. “Computational Discovery of Novel Trypanosomicidal Drug-like Chemicals by Using Bond-based Non-stochastic and Stochastic Quadratic Maps and Linear Discriminant Análisis”. European Journal of Pharmaceutical Sciences, 2010, 39(1-3), p. 30-36.

Astudillo S., L.; Vallejos, C.G.; Kouznetsov, V.V.; Gutierrez, C.M.; Meléndez Gómez, C.M.; Vargas Méndez, L.Y.; Bermúdez Jaimes, J.H. “Synthesis of new diversely-linked biquinoline derivatives through multi component imino Diels-Alder cycloaddition and intramolecular Friedel-Crafts cyclization”. Synthesis, 2010, 4, p. 593-600.

Camargo, H.A.; Henao, J.A.; Amado, D.F.; Kouznetsov, V.V. “Synthesis and X-ray diffraction data of the 1-N-(4-pyridylmethyl)amino naphthalene”. Powder Diffraction Journal, 2010, 25(1), p. 72-74.

Romero Bohórquez, A.R.; Kouznetsov, V.V. “An Efficient and Short Synthesis of 4-Aryl-3-methyl-tetrahydroquinolines from N-Benzylanilines and Propenylbenzenes through Cationic Imino Diels-Alder Reactions”. Synlett, 2010, 6, p. 970-972.

Bueno Sánchez, J.G.; Kouznetsov, V.V. “Antimycobacterial susceptibility testing methods for natural products research”. Braz. J. Microbiol., 2010, 41, p. 270-277.

Bedoya, L.M.; Abad, M.J.; Astudillo Saavedra, L.; Gutiérrez, C.M.; Kouznetsov, V.V.; Alcami, J.; Bermejo, P. “Quinoline-based compounds as modulators of HIV transcription through NF-B and SP-1 inhibition”. Antiviral Research, 2010, 87(3), p. 338-344.

Kouznetsov, V.V.; Merchan Arenas, D.R.; Arvelo, F.; Bello Forero, J.S.; Sojo, F.; Muñoz, A. “4-Hydroxy-3-metoxyphenyl substituted 3-methyl-tetrahydroquinoline derivatives obtained through imino Diels-Alder reactions as potential antitumoral agents”. Letters in Drug Design & Discovery, 2010, 7(9), p. 632-639.

Rojas Ruíz, F.A.; Merchan Arenas, D.R.; Pellón Comdom, R.F.; Kouznetsov, V.V. “Síntesis de ácidos N-fenil y N-bencilantranílicos mediante reacción de Ullmann y evaluación de su actividad antioxidante e inhibidora de acetilcolinesterasa”. Revista CENIC Ciencias Químicas, 2010, 41(2), p. 123-129.

Kouznetsov, V.V.; Meléndez Gómez, C.M.; Bermúdez Jaimes, J.H. “Transformations of 2-aryl-4-(2-oxopyrrolinidyl-1)-1,2,3,4-tetrahydroquinolines, cycloadducts of the BiCl3-catalyzed three component Povarov reaction: oxidation and reduction processes towards new potentially bioactive 2-arylquinoline derivatives”. J. Heterocyclic Chem., 2010, 47(5), p. 1148-1152.

Kouznetsov, V.V.; Vargas Méndez, L.Y.; Muñoz Acevedo, A. “3´,4´-Dihydrospiro[piperidine-4,2´-(1´H)quinoline] derivatives as new antioxidant agents with acetylcholinesterase inhibitory property”. Letters in Drug Design & Discovery, 2010, 7(10), p. 710-715.


2009

Kouznetsov, V.V.; Romero Bohórquez, A.R.; Astudillo S., L. “A convenient procedure for the synthesis of new α-pyridinyl substituted 7H-indeno[2,1-c]quinoline derivatives based on three-component imino Diels-Alder reaction”. Synthesis, 2009, (24), p. 4219-4225.

Kouznetsov, V.V.; Gómez-Barrio, A. “Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation”. Eur. J. Med. Chem., 2009, 44 (8), p. 3091-3113.

Kouznetsov, V.V.; Meléndez Gómez, C.M. “Búsqueda de nuevos agentes antiprotozoarios selectivos”. MedUNAB, 2009, 12 (1), p. 33-45.

Astudillo S., L.; Gutiérrez, C.M.; Gaete, H.; Kouznetsov, V.V.; Meléndez G., C.M.; Palenzula, A.; Vallejos, G. “Solvent-free Microwave-assisted Synthesis of New 2-Aryl-tetrahydroquinolines using Three-component Povarov Reaction”.  Lett. Org. Chem. 2009, 6 (3), p. 208-212.

Kouznetsov, V.V.; Merchan Arenas, D.R. “First green protocols for the large scale preparation of  γ-diisoeugenol and related dihydro(1H)indenes via formal [3+2] cycloaddition reactions”. Tetrahedron Lett., 2009, 50 (14), 1546-1549.

Kouznetsov, V.V. “Recent synthetic developments in a powerful imino Diels-Alder reaction (Povarov reaction): application to the synthesis of N-polyheterocycles and related alkaloids”. Tetrahedron, 2009, 65 (14), 2721-2750.


2008

Meneses-Marcel, A.; Rivera-Borroto, O.M.; Marrero-Ponce, Y.; Montero, A.; Machado Tugores, Y.; Escario, J.A.; Gómez-Barrio, A.; Montero Pereira, D.; Nogal, J.; Kouznetsov, V.V.; Ochoa Puentes, C.; Bohórquez, A.R.; Grau, R.; Torrens, F.; Ibarra-Velarde, F.; Ara, V.J. “New Antitrichomonal Drug-like Chemicals Selected by Bond (Edge)–Based TOMOCOMD-CARDD Descriptors”. Journal of Biomolecular Screening, 2008, 13, 785-794.

Kouznetsov, V.V.; Amado Torres, D.F. “Antimaláricos: construcción de híbridos moleculares de la cloroquina”. Universitas Scientiarum, 2008, 13 (3), 303-317.

Merchan, D.R.; Vargas, L.Y.; Kouznetsov, V.V. “Nuevos agentes inhibidores de la acetilcolinesterasa con fragmentos estructurales de lignanos”. Revista SaludUIS, 2008, 40(2), 166-168.

Astudillo S., L.; Vallejos, C.G.; Gutiérrez, C.M.; de la Guarda, W.; Kouznetsov V.V. “An Efficient Synthesis of 2,3-Diaryl-2-azabicyclooctanones via BiCl3-Catalyzed Three-Component aza Diels-Alder Reaction”. Lett. Org. Chem., 2008, 5(7), 559-562.

Hernández, J.G.; Vargas, L.Y.; Zacchino S.; Kouznetsov, V.V. “Evaluación de la actividad antifúngica de los extractos de Avicennia germinans sobre diversas cepas de hongos patógenos”. Revista SaludUIS, 2008, 40(2), 154-156.

Meléndez Gómez, C.M.; Kouznetsov, V.V.; Sortino, M.A.; Álvarez, S.L.; Zacchino, S.A. "In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions". Bioorg. Med. Chem., 2008, 16, 7908-7920.

Kouznetsov, V.V.; Bello Forero J.S.; Amado Torres, D.F. "A simple entry to novel spiro dihydroquinoline-oxindoles using Povarov reaction between 3-N-aryliminoisatins and isoeugenol". Tetrahedron Lett., 2008, 49, 5855-5857.

Kouznetsov, V.V.; Merchán-Arenas, D.R.; Romero-Bohórquez, A.R. "PEG-400 as green reaction medium for Lewis acid-promoted cycloaddition reactions with isoeugenol and anethole". Tetrahedron Lett., 2008, 49, 3097-3100.

Vargas Méndez, L.Y.; Kouznetsov, V.V. “An Efficient Preparation of New Homoallylamines and α-Aminonitriles Bering Furyl and Thienyl Rings”. J. Heterocycl. Chem., 2008, 45, 927-930.

Kouznetsov, V.V.; Vargas Méndez, L.Y. “Recent Developments in Three Component Grignard-Barbier-type Reactions”. Synthesis, 2008, 4, 491-506.

Hernandez Barajas, J.G.; Vargas Mendez, L.Y.; Kouznetsov, V.V.; Stashenko, E.E. “ Efficient Synthesis of New N-benzyl- or N-(2-Furylmethyl)cinnamamides Promoted by the “Green” Catalyst Boric Acid, and Their Spectral Analysis”. Synthesis, 2008, 3, 377-382.

Kouznetsov, V.V.; Vargas Méndez, L.Y.; Sortino, M.; Vásquez, Y.; Gupta, M.P.; Freile, M.; Enriz, R.D.; Zacchino, S.A. “Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment”. Bioorg. Med. Chem., 2008, 16, 794-809.


2007

Kouznetsov, V.V. ”Desarrollo de estrategias y tácticas en la síntesis de los alcaloides y sus análogos”. Scientia et Técnica, 2007, año XIII, No 33,1-4.

Solano Espinoza, E.A.; Stashenko, E.; Martínez, J.; Mora, U.; Kouznetsov, V. “Linear free energy relationships in C-N bond dissociations in molecular ions of 4-substituted N-(2-furylmethyl)anilines in the gas phase”. J. Mass Spectrom., 2007, 42,1496-1503.

Melendez Gómez, C.M.; Kouznetsov, V.V.; Astudillo, A. ”Síntesis de derivados del alcaloide dubamina vía reacción imino-Diels-Alder multi-componente”. Scientia et Técnica, 2007, año XIII, No 33, 369-372.

Bohórquez Romero, A.R.; Merchan Arenas, D.R.; Kouznetsov, V.V. ”Reacción de imino Diels-Alder de tres componentes con precursores de origen natural. Generación de nuevas tetrahidroquinolinas 2,4-diaril disustituidas”. Scientia et Técnica, 2007, año XIII, No 33, 91-95.

Kouznetsov, V.V.; Bohórquez Romero, A.R.; Stashenko, E.E. “Three-component imino Diels-Alder reaction with essential oil and seeds of anise: generation of new tetrahydroquinolines”. Tetrahedron Lett., 2007, 48, 8855-8860.

Viscaya, L.A.; Mora, A.J.; Vargas, L.Y.; Kouznetsov, V.V.; Bahsas, A. “6-Flouro-4-methyl-2-(3-pyridyl)-1,2,3,4-tetrahydroquinoline”. Acta Crystallographica Section C: structure reports (Acta Cryst.), 2007, E63, o2914.

Vargas Méndez, L.Y.; Kouznetsov, V.V. “4-Aminopiperidinas y espiro-4-piperidinas: Importancia farmacológica y esfuerzos sintéticos”. Universitas Scientiarum, 2007, 12 (2), 23-45.

Montaño, A.M.; Henao, J.A.; Vargas-Méndez, L.Y.; Kouznetsov, V.V.; Atencio, R. “4,6-Dimethyl-2-(3-pyridyl)quinoline-5-amine”. Acta Crystallographica Section C: Crystal Structure Communications (Acta Cryst.), 2007, C63, (4), 228-230.

Kouznetsov, V.V.; Vargas Méndez, L.Y.; Leal, S.M.; Mora Cruz, U.; Coronado, C.A.; Meléndez Gómez, C.M.; Romero Bohórquez, A.R.; Escobar Rivero, P. ”Target-Oriented Synthesis of Antiparasitic 2-Hetaryl Substituted Quinolines based on imino Diels-Alder reactions”. Letters in Drug Design & Discovery, 2007, 4, (4), 293-296.

Kouznetsov, V.V.; Meléndez Gómez, C.M.; Urbina González, J.M.; Stashenko, E.E.; Bahsas, A.; Amaro-Luis, J. “Synthesis and Spectral Data of Quinoline Products Obtained by Reaction of N-(4-Pyridinyliden)anilines and N-Benzylidenaniline with 2,2-Dimethoxypropane (Kametani Reaction)”. J. Heterocycl. Chem., 2007, 44, 551-555.

Vargas Méndez, L.Y.; Kouznetsov, V.V. “An Efficient Synthesis of New 1-H-4´-Methyl-3´,4´-Dihydrospiro[piperidine-4,2´(1´H)quinoline] Scaffolds”. Tetrahedron Lett., 2007, 48 (14), 2509-2512.

Kouznetsov, V.V.; Mora Cruz, U.; Zubkov, F.I.; Nikitina, E.V. ”An Efficient Synthesis of Isoindolo[2,1-a]quinoline Derivatives via Imino Diels-Alder and Intramolecular Diels-Alder with Furan Methodologies”. Synthesis, 2007, 3, 375-384.


2006

Kouznetsov, V.V.; Mora Cruz, U. “Transformations of 2-(α-furyl)-4-(2-oxopyrrolinidyl-1)-1,2,3,4-tetrahydroquinolines, cycloadducts of the imino Diels-Alder reaction: A Simple Synthesis of New Quinoline Derivatives”. Lett. Org. Chem., 2006, 3 (9), 699-702.

Solano, E.; Stashenko, E.; Martinez, J.; Mora, U.; Kouznetsov, V. “Ion [C5H5O]+ Formation in The Electron/Impact Mass Spectra of 4-Substituted N-(2-Furylmethyl)Anilines. Relative Abundance Prediction Ability of the DFT Calculations”. J. Mol. Structure (Theochem), 2006, 769, 83-85.

Kouznetsov, V.V.; Ochoa Puentes, C.; Bohórquez Romero, A.R.; Zacchino, S.A.; Sortino, M.; Gupta, M.; Vázquez, Y.; Bahsas, A.; Amaro-Luis, J. "A straightforward synthetic approach to antitumoral pyridinyl substituted 7H-indeno[2,1-c]quinoline derivatives via three-component imino Diels-Alder reaction". Lett. Org. Chem., 2006, 3 (4), 300-304.

Gómez-Barrio, A.; Montero-Pereira, D.; Nogal-Ruiz, J.J.; Escario, J.A.; Muelas-Serrano, S.; Kouznetsov, V.V.; Vargas Mendez, L.Y.; Urbina Gonzáles, J.M.; Ochoa, C. "Antiparasitic properties of homoallylamines and related compounds”. Acta Parasitologica, 2006, 51 (1), 73-78.

Suvire, D.F.; Sortino, M.; Kouznetsov, V.V.; Vargas M., L.Y.; Zacchino, S.A.; Mora Cruz, U.; Enriz, R.D. "Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents". Bioorg. Med. Chem., 2006, 14, 1851-1862.

Kouznetsov, V.V.; Amado, D.F.; Bahsas, A.; Amaro-Luis, J. ”Synthesis and Spectral Data of New 1,2-Bis-(2-hetaryl-4-oxothiazolidin-3-yl)ethanes and 1,4-Bis-(2-hetaryl-4-oxothiazolidin-3-yl)butanes”. J. Heterocycl. Chem., 2006, 43 (2), 447-452.

Kouznetsov, V.V.; Bohórquez Romero, A.R.; Astudillo Saavedra, L.; Fierro Medina, R. "An efficient synthesis of new C-2 aryl substituted quinolines based on three component imino Diels-Alder reaction". Molecular Diversity, 2006, 10 (1), 29-37.

Schobert, R.; Dietrich, M.; Mullen, G.; Urbina-Gonzalez, J.M. "Phosphorus Ylide Based Functionalizations of Tetronic and Tetramic Acids". Synthesis, 2006, 22, 3902-3914.


2005

Schobert, R.; Urbina-González, J.M. "Annulated butanolides by ring closing metathesis of diallyltetronic acid derivatives". Tetrahedron Lett., 2005, 46, 3657-3660.

Meléndez Gómez, C.; Kouznetsov, V. “Alcaloides quinolínicos: importancia biológica y esfuerzos sintéticos”. Universitas Scientiarum, 2005, 10 (2), 5-18.

Kouznetsov, V.V.; Urbina G., J.M.; Stashenko, E.E. “N-Functionalization of dihydrocarvone: obtaining aminocyclohexane derivatives and their spectrometric study”. J. Chil. Soc. Chem., 2005, 50 (3), 447-451.

Kouznetsov, V.V.; Rivero Castro, J.; Ochoa Puentes, C.; Stashenko, E.E.; Martínez, J.R.; Ochoa, C.; Montoro Pereira, D.; Nogal Ruiz, J.J.; Fernández Portillo, C.; Muelas Serrano, S.; Gómez Barrio, A.; Bahsas, A.; Amaro-Luis, J. ” Synthesis and Antiparasitic Properties of New 4-N-Benzylamino-4-Heteroarylbut-1-enes. 5”. Archiv der Pharmazie, 2005, 338 (1), p. 32-37.

Pinto, J.L.; Henao, J.A.; Rodriguez, W.; Kouznetsov, V.V. “Synthesis and Structural Characterization of 3-(4-fluorophenyl)-2-(a-naphtyl)-1,3-thiazolidin-4-one”, Abstr. En XX Congress of the International Union of Crystallography- IUCr-2005, Florence, Italy, August 23-31, 2005; P.05.08.4; published in Acta Cryst., 2005, A61, C278.

Kouznetsov, V.V. “Quinolines spiro annulated at heterocyclic fragment: synthesis and properties”. J. Heterocycl. Chem., 2005, 42, p.39-59.

Kouznetsov, V.V.; Díaz P., B.; Sanabria M., C.M.; Vargas M., L.Y.; Poveda, J.C.; Stashenko, E.E.; Bahsas, A.; Amaro-Luis, J. “Synthesis and Transformations of New Spiro-4-piperidines. Acetyl Migration in 1-Acetyl-1’-Benzyl-4-Methyl-3,4-Dihydrospiro[(1H)quinoline-2,4’-piperidines] under Debenzylation Conditions”. Lett. Org. Chem., 2005, 2 (1), p. 29-32.

Kouznetsov, V.V.; Vargas Méndez, L.Y.; Meléndez Gómez, C.M. "Recent progress in the synthesis of quinolines". Curr. Org. Chem., 2005, 9 (2), p. 141-161.

Kouznetsov, V.V.; Avellaneda Duarte, L.D.; Stashenko, E.E. “A simple and efficient synthesis of new dihydrospiro[(1H)quinoline-2,1’-cyclohexane] derivatives via internal Friedel-Crafts alkene alkylation of N-(1-allylcyclohexanyl) ethylphenylamine”. Synth. Commun., 2005, 35 (4) p. 639-647.
 

NOTICIAS
El LQOBio participa activamente en el 31º Congreso Latinoamericano de Química - CLAQ2014, celebrado en Lima, Perú. ( Ver más... ).

PRÓXIMO SEMINARIO
Jueves 25 de febrero de 2016
10:00 a.m.
CENTIC - Sala de reuniones 5

TEMA DEL SEMINARIO
Síntesis de nuevas tetrahidroisoquinolinas y beta-carbolinas como análogos estructurales del alcaloide Dysoxylum y Harmala y su evaluación biológica empleando el modelo del pez cebra, a cargo de Carlos Eduardo PUERTO GALVIS, estudiante de Doctorado en Química.

Última actualización:
24 de febrero de 2016